Recent studies have reported that GL and its derivatives can bind to PGRMC1 (progesterone receptor membrane component 1), inhibit the interaction between PGRMC1 and EGFR (Epidermal growth factor receptor), then inhibit HCT116 and HuH7 cancer cell proliferation, while GA does not bind to PGRMC1 (Kabe et al., 2021). The gene discussed is PGRMC1; the disease is cancer.