1. Inflammation: LPS, IL-18, IL-1β, IL-6 and TNF-α↓; 2. Insulin resistance indicators: HOMA-IR↓; 3. Intestinal barrier: occluding and claudin-1↓; 4. Signaling pathway: TLR4/NF-κB↓. The gene discussed is TNF; the disease is Insulin resistance.