SHBG and polycystic ovary syndrome: Probiotic supplementation in women with PCOS is beneficial in reducing body weight, improving hormone levels and IR, lowering triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) concentrations, increasing sex hormone-binding globulin (SHBG) and improving inflammation and oxidative stress, suggesting that probiotics can modulate inflammation in patients with PCOS (Shoaei et al., 2015; Jamilian et al., 2018).