INS and polycystic ovary syndrome: Glycyrrhizin and total saponins of glycyrrhizin are triterpenoids extracted from Glycyrrhiza glabra L [Fabaceae; Glycyrrhizae radix et rhizoma] with anti-inflammatory effects that could improve ovarian morphology, reduce androgen secretion levels and enhance insulin sensitivity in a letrozole-induced PCOS rat models (Jiang L. et al., 2020).