Naringenin, a citrus flavonoid, was recently found to have beneficial effects in the treatment of PCOS by upregulating the expression of PGC-1α, SIRT1, occludin and claudin-1 in the colon and downregulating the abundance of Prevotella and Gemera to improve the intestinal mucosal barrier and glucose metabolic pathways in PCOS rats (Wu Y. X. et al., 2022). This evidence concerns the gene PPARGC1A and polycystic ovary syndrome.