Celastrol could regulate BM-MSCs fate and bone-fat balance in OP and skeletal aging by stimulating PGC-1α. In addition, Celastrol inhibits glucocorticoid-induced osteoporosis in rat via the PI3K/AKT and Wnt signaling pathways. And Celastrol Attenuates RANKL-Induced Osteoclastogenesis in vitro. This evidence concerns the gene PPARGC1A and osteoporosis.