These results lend support to previous observations that ADAM17 systemic knockdown prevented cardiac hypertrophy and myocardial fibrosis in spontaneously hypertensive rodents (Wang et al., 2009), and ADAM17 antibody prevented cardiac hypertrophy and fibrosis induced by Ang II infusion (Takayanagi et al., 2016). Here, ADAM17 is linked to Myocardial fibrosis.