ADAM17 and familial dilated cardiomyopathy: Finally, it has been shown that oxidative stress plays a major role in myocardial ischemia reperfusion injury (Chen et al., 2021; Zhao et al., 2022) and DCM (Ren et al., 2020), and it requires further investigation whether the therapeutic effects of ADAM17 knockdown on DCM involve suppression of oxidative stress.