CCL2 and congenital rubella syndrome: Pennisi et al. (2021) found that the modified endothelial activation and stress index (EASIX) score (lactate dehydrogenase [LDH; U/L] × C-reactive protein [CRP; mg/dl]/platelets [PLTs; 109 cells/L]) is the most clinically relevant formula for predicting severe CRS and ICANS. Hay et al. (2017) designed a simple two-step algorithm to predict grade ≥4 CRS; they first checked whether the patient had a fever ≥38.9°C within 36 h of CAR-T infusion and then performed serum MCP-1.