Medication use and comorbidities were also related to MRED as follows: antipsychotic (aOR 1.86; 95% CI 1.41–2.46), anticoagulant (aOR 1.82; 95% CI 1.44–2.28), strong anticholinergic drugs (aOR 1.57; 95% CI 1.12–2.22), traditional nonsteroidal anti-inflammatory drugs (tNSAID) without the use of proton pump inhibitor (PPI) (aOR 1.44; 95% CI 1.15–1.81), insulin (aOR 1.39; 95% CI 1.03–1.88), diuretics (aOR 1.28; 95% CI 1.08–1.52), P2Y12 inhibitor (aOR 1.27; 95% CI 1.01–1.60) benzodiazepines (aOR 1.26; 95% CI 1.04–1.53), and ischemic heart disease (aOR 1.19; 95% CI 1.01–1.40) (Table 4). This evidence concerns the gene P2RY12 and coronary artery disorder.