TLR2 signalling pathways induce translocation of NF-κB into the nucleus and eventually modulate transcription of genes, as well as the production of inflammatory cytokines, considered to be the major hepatotoxic mediators that participate in the pathological process of liver fibrosis (Simeonova et al., 2001; Yang et al., 2020; Getachew et al., 2021). This evidence concerns the gene TLR2 and Hepatic fibrosis.