In this study, we determined that LWPE is the main effective fraction of AEPE against liver fibrosis, and proteomics and bioinformatics analysis showed that LWPE can regulate multiple targets including COL1A2, ITGAV, TLR2, ACE, and PDGFRB, etc., ECM-receptor interaction, focal adhesion and the PI3K-Akt signalling pathway and other pathways to exert antifibrosis effects. This evidence concerns the gene ITGAV and Hepatic fibrosis.