After CME treatment, gout group genes AQP3, SPTLC3, PCK1, ALDH3A1, SCARA5, EVPL, TSC22D3, CLEC3B, KLHDC8A, and AABR07034730.2 were significantly up-regulated, gout group genes PCSK5, F9F7, LIF, IL-6, MAB21L3, KIF26B, CCL20, IL- 1β, CXCL6 and GPR39 were significantly down regulated (Figure 3D). Here, GPR39 is linked to gout.