NLRP3 and IL-1β have been identified as risk factors for gout, and it has been clinically confirmed that high levels of NLRP3, Caspase-1, IL-1β and IL-6 have been detected in serum and synovial fluid of patients (Son et al., 2013; Cavalcanti et al., 2016). The gene discussed is NLRP3; the disease is gout.