We have recently demonstrated that, among 12 Gγ subunits, Gγ9 is the most Golgi-translocating Gγ subunit, whereas Gγ3 is the least GA-translocating Gγ subunit in prostate cancer cells and that the chemokine receptor CXCR4 activates ERK1/2 through a novel pathway involving Gβγ translocation to the GA and PI3Kγ activation (Khater et al., 2021b). The gene discussed is CFB; the disease is Familial prostate cancer.