We have recently identified a novel function for Gβγ translocation to the GA to activate the MAPKs ERK1/2 in prostate cancer cells and this function is mediated through phosphoinositide 3-kinase γ (PI3Kγ), a well-characterized Gβγ downstream effector, and the small GTPase ADP-ribosylation factor 1 (ARF1) (Khater et al., 2021a; Khater et al., 2021b). Here, MAPK3 is linked to Familial prostate cancer.