IL17A and Alzheimer disease: Our study showed that AESS can inhibit Th17 cell responses (both Th17 cells and serum IL-17 levels) in an AD mouse model, inhibit keratinocyte apoptosis, and inhibit adhesion to monocytes and inflammatory cytokines (including IL-17) in an AD cell model, indicating that AESS plays a role in both acute phase inflammation and the skin barrier via the Th17 cell response in AD.