Obeticholic acid (OCA), an FXR agonist, prevents the activation of HSCs and reduces the fiber generates related to protein, such as Col1a1, α-smooth muscle actin, and tissue inhibitors of metalloproteinases-1, -2, significantly contributing to the improvement in liver fibrosis (Zhou et al., 2020). Here, COL1A1 is linked to Hepatic fibrosis.