As a result, six kinds of immune cells, including nTreg, T helper 1 cell (Th1), Th17, dendritic cell (DC), CD4+ T cell, and CD8+ T cell, were developed as a promising predictive signature for prognostic assessment for PaCa patients. The gene discussed is CD8A; the disease is permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome.