GMDS and glaucoma: To date, the response to latanoprost of patients with glaucoma and ocular hypertension, is reported to be associated with the genetic polymorphism of seven genes (ABCB1, SLCO2A1, AFAP1, GMDS, PTGS1, MRP4, and PTGFR) (McCarty et al., 2012; Sakurai et al., 2014; Gao et al., 2015; Ussa et al., 2015; Liu et al., 2016; Zhang et al., 2016; Cui et al., 2017) (Figure 2).