Dioscin, which is a natural steroid saponin derived from a variety of plants, could reduce the Skp2 protein expression by reducing the stability of Skp2, promoting Skp2 ubiquitination, inhibiting Skp2 expression and thus delaying tumor growth in vivo, and all these suggested that enhancement of ubiquitination-dependent Skp2 turnover had great potential for cancer therapy. The gene discussed is SKP2; the disease is cancer.