2) TAMs directly enhances the migration and the aggressiveness of tumor cells through the paracrine loop between macrophages and tumor cells, in which the secretion of colony stimulating factor 1 (CSF1) by tumor cells and epidermal growth factor (EGF) family ligands by macrophages are critically involved (Vitale et al., 2021). The gene discussed is CSF1; the disease is neoplasm.