CXCR2 and neoplasm: For example, the oncogenic gene RAS drives multiple inflammatory cytokines (IL-1, IL-6, IL-8, IL-23, etc.)/chemokines [chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL2, CXCL5, CXCL8, and C-X-C motif chemokine receptor 2 (CXCR2), etc.] and signaling pathways [STAT3, NF-κB, mitogen-activated protein kinase (MAPK)] that promote tumor progression (Hamarsheh et al., 2020).