M1 macrophages have the positive anti-tumor activity by upregulating the production of cytokines such as IL-6 and IL-1, which activate the T helper type 1 (Th1) reaction and further produce TNF-α, ROS, RNS, and other toxic substances to kill tumors and pathogenic microorganisms (Arora et al., 2018). Here, IL6 is linked to neoplasm.