Subsequently, TAMs typically accumulates around blood vessels and tumor margins and produces various proteases such as urokinase-type fibrinogen activator (uPA) and metalloproteinase 9 (MMP9) that regulate adaptive immunity to promote ECM remodeling, degradation of basement membrane and tumor cell invasion (Mekkawy, Pourgholami and Morris 2014). Here, MMP9 is linked to neoplasm.