The cysteine-type endopeptidase involved in apoptotic processes, endodeoxyribonuclease, Tat protein, apolipoprotein, unfolded protein, ribosomal small subunit, core promoter binding, and DNA replication origin binding that are regulated by caspase 7 (CASP7), TatD DNase domain-containing 2 (TATDN2), nucleophosmin 1 (NPM1), heat shock protein family D member 1 (HSPD1), and RNA polymerase I transcription factor 3 (RRN3), were highly expressed in asthma patients after ICS/LABA treatment and normal subjects. The gene discussed is NPM1; the disease is asthma.