As in the case of acute HIV-1 infection 29 and HIV-1 dissemination to CD4+ T cells 46, identifying SARS-CoV-2 role in the expression of the chemokines/chemokine receptors responsible for mononuclear cell trafficking and tissue infiltration observed in post-mortem analysis of COVID-19 patients 47, will be important. This evidence concerns the gene CD4 and COVID-19.