PDP1 and amyotrophic lateral sclerosis: This included sodium dichloroacetate (DCA), a compound that improves the functional status of mitochondria through the stimulation of the pyruvate dehydrogenase (PDH) activity, and has shown health benefits in animals, including in nematodes and in an Amyotrophic Lateral Sclerosis (ALS) mouse model (Schaffer et al., 2011; Miquel et al., 2012).