GEO datasets (GSE40435, GSE53757), E-MTAB-3267, and three Oncomine datasets (Lenburg, Gumz, and Beroukhim) all showed that FXYD2 mRNA expression was downregulated in ccRCC samples compared to paracancerous normal samples (P < 0.05) (Figures 1(a)–1(f)). This evidence concerns the gene FXYD2 and nonpapillary renal cell carcinoma.