Therefore, taken our results and previous findings together, the function of FXYD2 expression in the prognosis and immune cell infiltration in ccRCC may correlate with TGF-β-SMAD2/3, Notch, and PI3K-Akt-mTOR signaling pathways (Figure 6). This evidence concerns the gene FXYD2 and nonpapillary renal cell carcinoma.