The results established a clear dependence on CD8+ Tcells, as tumor growth for those mice was comparable to that of thePBS-treated group (Figure 5b), as is observed with many immunotherapies.43 Although our previous work demonstrated the importanceof CD4+-T cell-mediated humoral response in a vaccinationsetting,22 in the tumor setting, CD4 depletiondid not affect the therapeutic efficacy, likely due to depletion ofregulatory T cells. This evidence concerns the gene CD8A and neoplasm.