CD44 and cancer: This was notsurprising as the action of multiple proteases within biological pathwayssuggests that there is not a specific proteolytic profile common toall cancers.9 Under the influence of eitheroncogene, for example, we observed increased proteolysis of proteinswith important roles in cell growth, proliferation, and metastasis.These effects included increased juxtamembrane shedding of syndecan-4and CD44, which are cut by ADAM- and metalloproteases to release theirsoluble domains.