Consistently, Notch2 signalinghas been reported to be up- or downregulated in different cancer cellsand may either promote or suppress tumor growth.49 Of note, most oncogene-induced proteolytic modificationswe identified were either poorly characterized or previously not annotated.Looking forward, future biochemical and cellular experiments are necessaryto understand how cleavage events are regulated and the functionalconsequences of proteolytic modifications. Here, NOTCH2 is linked to cancer.