STINGis a facilitator of innate immune signaling that mediates the responseto cytosolic DNAs from bacteria, viruses, and cancer cells, and promotesthe production of IFN-I.41 Essential genesdownstream of STING-ligand binding, such as SEC24C42 and IRF3,43 were also identifiedas top-ranked genes in the CRISPR screening (Figure 1g & 1h). This evidence concerns the gene IRF3 and cancer.