SREBF1 and craniosynostosis: Moreover, our finding is also in agreement with previous studies, which have shown that CSO pretreatment increased expression of genes related to de novo synthesis of fatty acids, such as SREBP-1c, in differentiated bovine mammary epithelial cells (48), and have found that the degree of lipid droplet accumulation in the hepatocytes in the CSO-fed group was lower than that in the olive oil-fed group, but higher than that in the soybean oil-fed group via the cytological observation (49).