The higher incidence of anxiety and depression with less irritability is also well represented in PSEN1 and PSEN2 (Kaiser et al., 2014; Panegyres and Chen, 2014), but they tend to have more hallucinations and delusions compared with APP mutations (Larner and Doran, 2006; Canevelli et al., 2014). The gene discussed is APP; the disease is major depressive disorder.