Besides chemical inducers, transgenic animal models are also used to investigate the phenotypes of specific mutations in PD-related genes such as PTEN-induced putative kinase 1 (PINK1), DJ-1, and Parkin (Kitada et al., 1998; Bonifati et al., 2003; Valente Enza et al., 2004). This evidence concerns the gene PRKN and Parkinson disease.