Interestingly, multiple NLRP3 inflammasome-related proteins, including NLRP3, ASC, caspase-1, and IL-1β, as well as α-synuclein proteins were detected in PD patient’s serum or plasma (Lin et al., 2017; Fan et al., 2020; Anderson et al., 2021). Here, SNCA is linked to Parkinson disease.