AD-KD • Significant decrease in number of bacterial species. • Decrease Shannon Index compared to AD-CON • Increase: Phylum Proteobacteria (Enterobacteriales) • Increase in B-amyloid deposition and tau phosphorylation • Decrease in Akt phosphorylationAD-IMF • Decrease: Clostridales, • Increase: Lactobacillales. Here, AKT1 is linked to Alzheimer disease.