Therefore, since our previous data showed that OlGly has a protective role in a mouse model of mTBI (Piscitelli et al., 2020) and is able to act through PPARα (Donvito et al., 2019), we decided to investigate the effect of this eCBome mediator in our in vitro model of MPP+-induced neurotoxicity. The gene discussed is PPARA; the disease is concussion.