It was found that LH-1 had a selective inhibitory effect on melanoma cells and had no significant toxicity to human breast cancer cell MDA-MB-231 (IC50 > 60 μM at 72 h), human carcinoma cell A549 (IC50 > 60 μM at 72 h) and human renal epithelial cell HEK-293T (IC50 > 50 μM at 72 h) (Figure 2A and Supplementary Figure 10). Here, PLOD1 is linked to carcinoma.