It has been reported that giant obscurin regulates migration and metastasis in pancreatic cancer (Tuntithavornwat et al., 2022), and the loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity, and metastasis (Shriver et al., 2015). The gene discussed is OBSCN; the disease is familial pancreatic carcinoma.