LasB, a prominent virulence factor and metalloprotease identified in PAO1, have been shown to degrade interleukin 6 (IL-6), an early immune responder to infection, and trappin-2, an antimicrobial molecule secreted from epithelial cells, in vitro and in vivo (Tanaka et al., 2014; Saint-Criq et al., 2018). Here, PI3 is linked to infection.