Between the dMMR and pMMR groups, significant differences were observed in tumor location, tumor size, differentiation, pN stage, American Joint Committee on Cancer (AJCC) TNM stage, distant metastases, tumor nodules and nerve invasion, while there were no statistically significant differences in age, gender, pathological type, pT Stage, liver metastasis, vascular tumor embolus and KRAS/NRAS/BRAF status (p > 0.05). This evidence concerns the gene NRAS and metastasis.