CFTR and cystic fibrosis: Several assigned functions to this host signal were previously and directly linked to the CF-affected airways, such as complement cascade, signaling by interleukins and defective CFTR, apoptotic execution phase and programmed cell death (Soleti et al., 2013), scavenging of heme (Tyrrell and Callaghan, 2016), autophagy (Bodas and Vij, 2019; Zhao et al., 2020), cellular response to stress or antimicrobial peptides (Laube et al., 2006; Lecaille et al., 2016).