For instance, GLP-1-expressing Lactobacillus could reduce the incidence of high-fat diet-induced obesity in mice by restraining lipid accumulation, enhancing GLP-1 resistance to glucose intolerance, and increasing the expression of genes involved in the triglyceride degradation pathway (Wang et al., 2021). The gene discussed is GCG; the disease is obesity due to melanocortin 4 receptor deficiency.