The CRS model was based on seven genes: namely, CLCX12, SERPINB7, CRISPLD2, EML1, TRPC4, SLC16A3, and ANLN. To the best of our knowledge, few studies have evaluated the role of SERPINB7, CRISPLD2, EML1, and TRPC4 in BLCA. Here, EML1 is linked to congenital rubella syndrome.