The CRS model was based on seven genes: namely, CLCX12, SERPINB7, CRISPLD2, EML1, TRPC4, SLC16A3, and ANLN. To the best of our knowledge, few studies have evaluated the role of SERPINB7, CRISPLD2, EML1, and TRPC4 in BLCA. Here, CRISPLD2 is linked to bladder transitional cell carcinoma.