The CRS model was based on seven genes: namely, CLCX12, SERPINB7, CRISPLD2, EML1, TRPC4, SLC16A3, and ANLN. To the best of our knowledge, few studies have evaluated the role of SERPINB7, CRISPLD2, EML1, and TRPC4 in BLCA. This evidence concerns the gene SERPINB7 and bladder transitional cell carcinoma.