When the differences in BLCA characteristic pathway scores between the high- and low-CRS subgroups were investigated, we observed that the basal differentiation, EMT differentiation, immune differentiation, interferon response, keratinisation, myofibroblast, and neuroendocrine differentiation pathways were highly enriched in the high-CRS subgroup, whereas the luminal differentiation and Ta pathways were high in the low-CRS group in the two cohorts (Figure 5(d) and Supplementary Table 7). The gene discussed is TOR1A; the disease is congenital rubella syndrome.