TP53 and liver disorder: Inflammatory cells generate soluble medium such as arachidonic acid metabolites, chemokines, and cytokines induce inflammatory factors to the injury, oxidative stress, and inflammation in the liver disease development to play the role of a mutual promotion, oxidative stress can through signal transduction pathways (including P53) promote the expression of proinflammatory genes that cause inflammation, inflammation further enhances oxidative stress by releasing more free radicals [22].