TP53 and pulmonary arterial hypertension: In this study, we believe that P53 signaling pathway/telomere dysfunction may be the pathogenesis of the disease, and the mechanism (Figure 6) may be that oxidative stress and inflammation lead to telomere dysfunction, induce P53 activation, telomere dysfunction, and excessive activation of P53 induces oxidative stress, inflammation, etc., promoting pulmonary vascular cell aging and dysfunction, and reduced NO secretion leads to vasodilation dysfunction, which leads to the formation of pulmonary hypertension.