Chan et al. used affinity-based aptamer probes, cross-referenced to single-cell transcriptomic analysis to explore protein candidates related to post-MI heart failure (HF), and identified 83 proteins as potential biomarkers, of which 4 highest-priority are nascent (angiopoietin-2, thrombospondin-2, latent transforming growth factor beta binding protein 4, and follistatin-related protein 3) Chan et al. (2020). The gene discussed is THBS2; the disease is heart failure.