The investigation of the potential confounding effect of inflammatory and hemostasis biomarkers on the association between fibrinogen and CRC showed that (a) high sensitive-C reactive protein (hs-CRP) reduced the magnitude of the association and (b) the inclusion of hemostasis biomarkers (D-dimer or tissue plasminogen activator (tPA)) moderately increased the previous results (Table 3). This evidence concerns the gene CRP and colorectal carcinoma.