The first one showed the predictive role of plasminogen activator inhibitor-1 for both CVD and the occurrence of breast and colorectal cancer in a European cohort (46); the second one observed that elevated levels of tPA, a fibrinolytic protein with a well-known role in CVD risk, is a potential predictor for breast cancer in Moli-sani women (47). The gene discussed is SERPINE1; the disease is breast carcinoma.