ApoA-I110−525 combined with FRS predicted the presence of coronary atherosclerosis with a similar accuracy to FRS alone [AUC (95% CI): 0.65 (0.57–0.72) vs. 0.64 (0.57–0.72)] in the whole population, [0.60 (0.46–0.75) vs. 0.55 (0.41–0.69)] in LLM users, and [0.73 (0.64–0.82) vs. 0.71 (0.62–0.81)] in patients not using LLM (P-values on comparison between ROCs > 0.05) (Figure 3). This evidence concerns the gene APOA1 and coronary atherosclerosis.