The level of TIMP-1 in the recurrence group was significantly higher than that in the non-recurrence group (129.8 ± 65.7 ng/ml vs. 112.0 ± 51.0 ng/ml, P = 0.041), and participants with AF recurrence had a significantly higher level of hs-CRP than those without AF recurrence (3.9 ± 6.0 mg/L vs. 1.9 ± 2.8 mg/L, P < 0.05). The gene discussed is TIMP1; the disease is atrial fibrillation.