KANSL1 and heart disorder: Moreover, other regulatory factors of autophagy, including KAT8 Regulatory NSL complex subunit 1 (KANSL1) (31), Lysosome-associated membrane protein 2 (LAMP2) (32–34), insulin-like growth factor 1 receptor (IGF1R) (35) and HDAC (36, 37), also play imperative roles in maintaining cardiac fitness, and their abnormality leads to heart diseases.