Moreover, other regulatory factors of autophagy, including KAT8 Regulatory NSL complex subunit 1 (KANSL1) (31), Lysosome-associated membrane protein 2 (LAMP2) (32–34), insulin-like growth factor 1 receptor (IGF1R) (35) and HDAC (36, 37), also play imperative roles in maintaining cardiac fitness, and their abnormality leads to heart diseases. This evidence concerns the gene IGF1R and heart disorder.