This tenet is further supported by recent findings demonstrating that suppression of the prostaglandin-degrading enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH or HPGD) slowed sarcopenia progression partly through activating autophagy (98) and that exerkine apelin reversed sarcopenia partially by triggering autophagy in mice and humans (99). Here, HPGD is linked to sarcopenia.