Similarly, hypomethylation of TNF receptor-associated factor 3 (TRAF3) and hypermethylation of thrombospondin-1 (THBS1) has also been illustrated to be crucial predictor of stroke-related outcomes (Lopez-Dee et al., 2011; Udali et al., 2013; Gallego-Fabrega et al., 2016; Ng et al., 2018). This evidence concerns the gene THBS1 and Stroke.