A neoteric study was conducted in murine specie (mouse), demonstrating the use of ascorbate (mineral salt of ascorbic acid; vitamin C) in post-stroke reperfusion led to Ten-eleven translocation 3 (TET3) dependent conversion of 5mC to 5hmC, promoting up-regulation of neuroprotective genes and functional recovery (Morris-Blanco et al., 2019). Here, TET3 is linked to stroke disorder.