Four weeks after CL, HF + Scr siRNA rats exhibited markedly increased mRNA expression of inflammatory cytokines TNF-α (Figure 4A), IL-1β (Figure 4B), IL-6 (Figure 4C), and chemokines MCP-1 (Figure 4D), MIP-1α (Figure 4E), SDF-1 (Figure 4F) in the PVN, compared with SHAM + Scr siRNA rats. The gene discussed is TNF; the disease is hydrops fetalis.