REN and hydrops fetalis: It is worth noting that the levels of most proinflammatory mediators in the PVN in HF animals treated with IL-17RA siRNA still remain higher than those in SHAM animals, implying that other mechanisms such as the brain renin-angiotensin system may also contribute to the neuroinflammatory response in the brain in HF (Yu et al., 2018; Diaz et al., 2020).