After induction of hyperandrogenism in rats by 7 days of administration of DHT, estrous cyclicity determined by vaginal smear was not drastically disrupted, and the expression levels of gonadotropin Cga, Lhb, and Fshb genes were unchanged; however, Prl gene expression was repressed in the pituitary gland. The gene discussed is PRL; the disease is hyperandrogenism.