LGALS9 and COVID-19: Based on different structures, galectin can be divided into Gal-1, Gal-3, and Gal-9.77 All of the Gal proteins can be detected in APC cells (macrophages, monocytes, and DCs) and plasma from COVID-19 patients, which are considered to be associated with “cytokine storm syndrome” and severe disease course.29 Interestingly, Gal-9 appears to have higher expression in activated HLA-DR+ and CD80+ monocytes, whereas Gal-9 is down-regulated in activated neutrophils.78