To study the antiviral effects of murine IFNα2, IFNα4, IFNα5, and IFNα11 on persistent viral infection using a replicating virus in vivo, mice received rAAV8-1.3HBV i.v. and 4 weeks post infection IFN-treatment was performed on 10 consecutive days. Here, IFNA5 is linked to viral infectious disease.