This study found that 13 lncRNAs (ADD3-AS1, AL356019.2, LEF1-AS1, LINC00346, WDR11-AS1, TMEM72-AS1, AC007744.1, AC073896.2, AL392083.1, AC062021.1, AC093726.1, AC093895.1, and NR2F2-AS1), which were inflammation-related based on functional analysis, were differentially expressed in gliomas and normal brain tissue, and they could independently and accurately predict the prognosis of patients. The gene discussed is LEF1; the disease is glioma.