The GISTIC 2.0 assessment uncovered numerous remarkable amplified regions containing multiple oncogenes in glioma patients with higher risk scores, consisting of 1q32.1 (PIK3C2B), 12q14·1(CDK4), 7p11·2 (EGFR), and 4q12 (PDGFRA). This evidence concerns the gene CDK4 and central nervous system cancer.