Subcutaneous syngeneic mouse tumor model/intratumoral OV injection: α-CTLA-4-encoding OV reduced tumor progression, whereas α-PD-L1- encoding OV prolonged survival both compared with control virus. Both antibody-encoding OVs increased T cell infiltration, decreased Treg infiltration and resulted in splenocyte activation (164). The gene discussed is CTLA4; the disease is neoplasm.