Co-cultures of infected tumor and unstimulated T cells or PBMCs: BiTE- encoding OV, not control virus, induced T cell activation, which depended on presence of EphA2-positive cells, and T cell-dependent bystander tumor cell killing. Lung metastasis xenograft mouse tumor model/intravenous OV and/or PBMC injection: BiTE-encoding OV showed significantly delayed tumor growth compared with controls (173). Here, EPHA2 is linked to neoplasm.