Subcutaneous syngeneic mouse tumor model with hPD-L1-expressing mouse tumor cells/intratumoral OV injection: Antibody-encoding-OV or combination of parental OV + intraperitoneal scFv reduced tumor growth and improved survival in comparison to monotherapies, Increase of activated CD8+ T cells in spleen of mice cured after treatment with antibody-encoding-OV compared with normal mice (165). Here, CD8A is linked to neoplasm.