Through integrating a series of bioinformatics methods, seven hub ECMGs (i.e. LAMB3, LAMA3, ITGB6, ITGB4, ITGA2, LAMC2, and COL11A1) that has the potential to act as a new indicator of both the advancement and prognosis of PAAD were identified via our research. This evidence concerns the gene LAMB3 and pancreatic adenocarcinoma.