Surabhi and his colleagues reported that the collagen milieu promotes resistance to chemotherapy in PAAD via elevated histone H3K9 and H3K27 acetylation levels, as well as elevated expression levels of GCN5, PCAF, and p300 histone acetyltransferases, which indicated that ECM exerts profound epigenetic effects on PAAD cells (38). This evidence concerns the gene KAT2B and pancreatic adenocarcinoma.