Overall, we identified 7 hub ECMGs (i.e., LAMA3, ITGB6, ITGB4, ITGA2, LAMC2, COL11A1, LAMB3), which were not only differentially expressed in PAAD and adjoining/normal pancreas tissues but also remarkably linked to the prognosis and stage of PAAD. The gene discussed is ITGB6; the disease is pancreatic adenocarcinoma.