However, a recent study showed that individual ablation of TSLP, IL-25, or IL-33/ST2 has no effect on the development of T2 dependent inflammation driven by IL-4 and IL-13; while blockade of all three cytokines greatly reduced eosinophilia in mouse models of helminth-induced T2 inflammation and chronic allergic inflammation (152). The gene discussed is IL33; the disease is Increased total eosinophil count.