HLA-G is not yet fully investigated in liver cells.HLA-G receptors (ILT2, ILT4, KIR2DL4) are present on all immune cells. Microenvironmental factors may influence the production of HLA-G by various cells, including tumor cells, cells of the monocyte lineage, mast cells and biliary epithelial cells. This evidence concerns the gene KIR2DL4 and neoplasm.