SPI1 and sarcoidosis: SPI1, the TF with the greatest DTFI in MAM, was found to be a key determinant of CD4+ T-cells in the UIC STAR cohort and has specifically been proposed as an effector of the innate immune response that interacts with multiple genes previously associated with sarcoidosis including the STAT family transcription factors, FCγ receptors, and Toll receptors (66, 67, 79, 102–110).