Most intriguingly, we identified several aberrantly expressed key determinant genes including FCGR1A, ICAM1, IL15RA, and NOD2 in the UCSF cohort and CD300A, FCGR1A, G6PD, FCER1G, RAC1, SPI1 that have been previously described in sarcoidosis and have the potential to directly or indirectly dysregulate the TNF pathway (32, 66, 67, 79, 102–117). The gene discussed is SPI1; the disease is sarcoidosis.